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Dr. Greicius spearheads the lab's efforts in Alzheimer's Disease. The aim of the project is to develop a sensitive and specific imaging test for Alzheimer's disease. Currently the team is examining a particular neural network, known as the default mode network, which is tonically active during quiet rest. Using resting-state functional MRI we have shown that this network can be detected and quantified in an automated fashion and that, at the group level, the network is deficient in patients with Alzheimer's disease (though not in patients with dementia of other types). The next step is to refine this imaging test so that it can be used to diagnose Alzheimer's disease in individual patients.