The overall goal of this project is to understand the functional organization of human brain networks. One ongoing project examines resting state networks in three subject groups: A group with mild cognitive impairment (MCI), a group with mild-moderate AD, and a group of healthy older adults age- and gender-matched to subjects in the AD and MCI groups. The MCI group will be imaged at baseline and followed longitudinally with clinical and neuropsychological evaluations. The functional connectivity analysis will focus on a specific resting-state network (RSN) that incorporates several brain regions affected early in the course of AD including the posterior cingulate cortex (PCC), inferior parietal lobes, and hippocampus. .Related Publications Greicius, M. D., Krasnow, B., Reiss, A. L. & Menon, V. Functional connectivity in the resting brain: A network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A 100, 253-8 (2003). Abstract      PDF Greicius, M. D. & Menon, V. Default-mode activity during a passive sensory task: uncoupled from deactivation but impacting activation. J Cogn Neurosci 16, 1484-92 (2004). Abstract     PDF Greicius, M. D., Srivastava, G., Reiss, A. L. & Menon, V. Default mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from fMRI. Proc Nat. Acad. Sci. 101, 4267-42 (2004). Abstract      PDF